Learn About the Granuloma Annulare Over The Counter Treatment.Granuloma annulare is a skin condition that typically appears as a rash with raised bumps arranged in a circle or ring shape. It usually affects people between the ages of four and 34, although it can be seen in people of all ages. The exact cause of granuloma annulare is unknown; however, there are several possible treatments available, including topical over-the-counter remedies.We will discuss the definition, symptoms and causes of granuloma annulare as well as the different types of topical over-the-counter treatments that may be used to help treat this condition.